CyberinfraV1, Main, Exploration, bibRecord, 000712

Comparing Effectiveness of Top-Down and Bottom-Up Strategies in Containing Influenza

Identifieur interne : 000712 ( Main/Exploration ); précédent : 000711; suivant : 000713

Comparing Effectiveness of Top-Down and Bottom-Up Strategies in Containing Influenza

Auteurs : Achla Marathe [États-Unis] ; Bryan Lewis [États-Unis] ; Christopher Barrett [États-Unis] ; Jiangzhuo Chen [États-Unis] ; Madhav Marathe [États-Unis] ; Stephen Eubank [États-Unis] ; Yifei Ma [États-Unis]

Source :

PLoS ONE [ 1932-6203 ] ; 2011.

RBID : PMC:3178616

Abstract

This research compares the performance of bottom-up, self-motivated behavioral interventions with top-down interventions targeted at controlling an “Influenza-like-illness”. Both types of interventions use a variant of the ring strategy. In the first case, when the fraction of a person's direct contacts who are diagnosed exceeds a threshold, that person decides to seek prophylaxis, e.g. vaccine or antivirals; in the second case, we consider two intervention protocols, denoted Block and School: when a fraction of people who are diagnosed in a Census Block (resp., School) exceeds the threshold, prophylax the entire Block (resp., School). Results show that the bottom-up strategy outperforms the top-down strategies under our parameter settings. Even in situations where the Block strategy reduces the overall attack rate well, it incurs a much higher cost. These findings lend credence to the notion that if people used antivirals effectively, making them available quickly on demand to private citizens could be a very effective way to control an outbreak.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178616

DOI: 10.1371/journal.pone.0025149
PubMed: 21966439
PubMed Central: 3178616

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>This research compares the performance of bottom-up, self-motivated behavioral interventions with top-down interventions targeted at controlling an “Influenza-like-illness”. Both types of interventions use a variant of the <italic>ring strategy</italic>
. In the first case, when the fraction of a person's direct contacts who are diagnosed exceeds a threshold, that person decides to seek prophylaxis, e.g. vaccine or antivirals; in the second case, we consider two intervention protocols, denoted <italic>Block</italic>
 and <italic>School</italic>
: when a fraction of people who are diagnosed in a Census <italic>Block</italic>
 (resp., <italic>School</italic>
) exceeds the threshold, prophylax the entire <italic>Block</italic>
 (resp., <italic>School</italic>
). Results show that the bottom-up strategy outperforms the top-down strategies under our parameter settings. Even in situations where the <italic>Block</italic>
 strategy reduces the overall attack rate well, it incurs a much higher cost. These findings lend credence to the notion that if people used antivirals effectively, making them available quickly on demand to private citizens could be a very effective way to control an outbreak.</p>
</div>
</front>
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<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
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<author><name sortKey="Feng, X" uniqKey="Feng X">X Feng</name>
</author>
<author><name sortKey="Kumar, Vsa" uniqKey="Kumar V">VSA Kumar</name>
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<author><name sortKey="Marathe, M" uniqKey="Marathe M">M Marathe</name>
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<author><name sortKey="Eubank, S" uniqKey="Eubank S">S Eubank</name>
</author>
<author><name sortKey="Feng, X" uniqKey="Feng X">X Feng</name>
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<author><name sortKey="Marathe, M" uniqKey="Marathe M">M Marathe</name>
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</author>
<author><name sortKey="Leidig, J" uniqKey="Leidig J">J Leidig</name>
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<author><name sortKey="Marathe, A" uniqKey="Marathe A">A Marathe</name>
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<author><name sortKey="Marathe, M" uniqKey="Marathe M">M Marathe</name>
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<author><name sortKey="Guclu, H" uniqKey="Guclu H">H Guclu</name>
</author>
<author><name sortKey="Kumar, Va" uniqKey="Kumar V">VA Kumar</name>
</author>
<author><name sortKey="Marathe, M" uniqKey="Marathe M">M Marathe</name>
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</author>
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</author>
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</author>
<author><name sortKey="Hanshaworakul, W" uniqKey="Hanshaworakul W">W Hanshaworakul</name>
</author>
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<author><name sortKey="Berkbigler, K" uniqKey="Berkbigler K">K Berkbigler</name>
</author>
<author><name sortKey="Bisset, K" uniqKey="Bisset K">K Bisset</name>
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<tree><country name="États-Unis"><region name="Virginie"><name sortKey="Marathe, Achla" sort="Marathe, Achla" uniqKey="Marathe A" first="Achla" last="Marathe">Achla Marathe</name>
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<name sortKey="Chen, Jiangzhuo" sort="Chen, Jiangzhuo" uniqKey="Chen J" first="Jiangzhuo" last="Chen">Jiangzhuo Chen</name>
<name sortKey="Eubank, Stephen" sort="Eubank, Stephen" uniqKey="Eubank S" first="Stephen" last="Eubank">Stephen Eubank</name>
<name sortKey="Eubank, Stephen" sort="Eubank, Stephen" uniqKey="Eubank S" first="Stephen" last="Eubank">Stephen Eubank</name>
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<name sortKey="Ma, Yifei" sort="Ma, Yifei" uniqKey="Ma Y" first="Yifei" last="Ma">Yifei Ma</name>
<name sortKey="Marathe, Achla" sort="Marathe, Achla" uniqKey="Marathe A" first="Achla" last="Marathe">Achla Marathe</name>
<name sortKey="Marathe, Madhav" sort="Marathe, Madhav" uniqKey="Marathe M" first="Madhav" last="Marathe">Madhav Marathe</name>
<name sortKey="Marathe, Madhav" sort="Marathe, Madhav" uniqKey="Marathe M" first="Madhav" last="Marathe">Madhav Marathe</name>
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Comparing Effectiveness of Top-Down and Bottom-Up Strategies in Containing Influenza

Comparing Effectiveness of Top-Down and Bottom-Up Strategies in Containing Influenza

Source :

Abstract

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	Serveur d'exploration Cyberinfrastructure
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.